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Follistatin, also known as FST, is a glycoprotein that is released and was initially discovered to be a follicle-stimulating hormone inhibiting component in the fluid that surrounds ovarian follicles. A protein of 315 amino acids (aa) is encoded by the human folistatin cDNA. This protein has a signal sequence of 29 aa, an N-terminal unusual TGF provision allowing, three Follistatin regions that include EGF­like and kazal­like motifs, and a highly acidic C-terminal tail. Follistatin is a protein that is produced and binds to ligands of the TGF-Beta family. It then inhibits the ability of these ligands to reach signalling receptors, hence regulating the activity of the ligands. It was first identified as activin antagonists, the activity of which inhibits the production and release of the anterior pituitary FSH.

Follistatin is not only a natural antagonist, but it also has the ability to suppress the action of additional TGF-Beta ligands, such as BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is a protein that is expressed in a variety of organs, including the pituitary, the ovaries, the decidual cells of the endometrium, and other tissues. The amino acids 30-315 of the FST-315 protein are included in the recombinant human Follistatin 315 protein, which has a molecular weight of 34.7 kDa.


Follistatin has its effect by covalently linking to and blocking the activity of converting growth factor- (TGF-) peptides such myostatin, which is in charge of controlling and restricting the development of muscle tissue. A high level of myostatin can inhibit normal tissue function and lead to chronic illness in essential organs, tissues, and bone marrow. It is also important to note that protein may play a role in the regulation in muscle tissue scarring. This is something that should be brought to your attention.

In addition to inhibiting the degenerative effects of myostatin, follistatin also inhibits the pituitary gland’s production of follicle-stimulating hormone and the hormone’s release into the bloodstream (FSH). If a man has high FSH levels, it may be an indication that his testicles are not working properly. This disease inhibits normal hormonal action as well as the growth and regeneration of muscular tissue. Having FSH levels that are too low, on the other hand, might have a severe influence on both one’s health and their ability to reproduce.

Increased levels of FS were found up to 15 months after the first injection, whereas the administration of some myostatin inhibitors, such as Trichostatin A (TSA), is required on a regular basis. Because it does not require administration on a regular basis, follistatin is an appealing alternative treatment option for myostatin suppression.

The primary motivation behind the recent surge in interest shown by the scientific community in follistatin as well as other myostatin blockers is the quest for an alternate method to treat muscle disorders. The most common treatment option available today is androgen steroids, which are associated with a number of negative effects as well as potential dangers to the patient’s health in the long run.


Please take note that the dose information is provided solely for the purpose of scientific reference. SARMs Central does not support or encourage the ingestion of this chemical by humans or its usage by humans outside of a strictly regulated research setting (i.e. a lab).

If you have never used folistatin before, begin with a dosage of 100 mcg and gradually increase it to a maximum of 200 mcg until you get the desired result.

It is recommended that a high-calorie diet be followed while taking folismatin for the greatest possible results.

This formulation, like the vast majority of peptides, arrives in a dried state, which means that you will be responsible for reconstituting it yourself. When you do this, you must use water that is either bacteriostatic or sterile; either option is suitable for injections. After the powder in the vial has been diluted and turned into a liquid, it is extracted from the vial and injected with the use of insulin syringes. When it comes to injecting oneself, it is of the utmost importance to educate yourself and to exercise caution. Injections of peptides are often given intramuscularly or subcutaneously (IM or Subq).

Potential Side Effects

If the recommended dosage of follistatin is adhered to, there are no documented adverse effects associated with its use.

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