Replacements of Human Chorionic Gonadotropin (HCG) for Men Who Are Currently Undergoing Testosterone Treatment

According to the Food and Drug Administration (FDA), human chorionic gonadotropin, or HCG, will henceforth be considered a biologic product. Because of this change, pharmacists will no longer have the ability to compound HCG. Because of this widespread shift in the medical field, clinics that were previously treating men with HCG in combination with testosterone therapy will be required to switch to employing other therapies. HCG was utilised in males who were receiving exogenous testosterone in order to maintain their fertility as well as the size and function of their testicles. Gonadorelin and enclomiphene citrate are two options that have been validated by clinical testing and are hence acceptable. Find out more.

Gonadorelin: what exactly is it?


Gonadorelin is being used primarily for men who do not want to explore testicular volume changes while they are on TRT. It is also used for men who would like to preserve their sperm quality and capacity to make their own testosterone while they are on TRT. [Citation needed] [Citation needed] Gonadorelin is being used mainly for men who do not want to feel testicular volume changes while they are on TRT. We prescribe gonadorelin to men who are worried about the size of his testicles, infertility and sperm concentration, and the volume of their sperm. This is because gonadorelin not only stops or delays the process of testicular shrinkage, but it also keeps a man’s fertility intact.

There is a biochemical identity between gonadorelin and releasing hormone factor (GnRH). GnRH is secreted by the hypothalamus in a wave – like motion approximately per 2 hours in a normal and healthy young male. This activates the anterior pituitary to generate hormone levels (LH) or follicle stimulating peptide, which are both necessary for reproduction (FSH). In response to these pulses, the testicles produce testosterone, sperm, and other substances that are not directly involved in the process.

Human Chorionic Gonadotropin, or HCG, and Gonadorelin are two hormones that are frequently compared and contrasted with one another. Gnadorelin is expected to provide the same advantages as HCG when the appropriate dosage and frequency of administration are carried out. HCG is quite effective for the majority of males. In order to keep testicles functioning properly and prevent atrophy, human chorionic gonadotropin (HCG) was often given between two and three times each week. Unfortunately, this frequency is ineffective when used in conjunction with gonadorelin. A subcutaneous injection of gonadorelin must be administered once day, ideally around bedtime.

Testosterone’s Impact on the Body

Before going to bed each night, the patient is given one injection of gonadotropin as directed by their doctor in order to stimulate a considerable quantity of LH and FSH production. The amount of the medication and the number of times each day that the doctor recommends taking it varies quite a bit from one male patient to the next. Patients have a responsibility to be aware that hormone therapy, in whatever form, is an extremely customised kind of treatment. The appropriate dosage will be based on the responsiveness of the patient’s pituitary gland, the responsiveness of the patient’s testicles to their own luteinizing hormone (LH) and follicle stimulating (FSH), the amount that the patient normally aromatizes androgens to estradiol, the amount of body fat that the patient possesses, and other lifestyle factors such as diet, exercise, and sleep.

The majority of younger patients who are new to testosterone therapy and who are otherwise healthy will observe that gonadorelin will preserve testicular size and function. These patients are considered to be candidates for gonadorelin treatment. Patients who have been undergoing TRT with human chorionic gonadotropin (HCG) and are pleased with the benefits they have received from HCG will observe a slight reduction in testicular size during the first thirty to sixty days of treatment with gonadorelin; however, this change will reverse itself over the course of the treatment. Patients who have been receiving TRT without HCG may observe that it may take one or two months, or even more, for the noticeable effects of gonadorelin to begin to manifest themselves. It is essential to be aware that human chorionic gonadotropin, often known as HCG, does not work for all men, just as gonadorelin does not work for all men. Talk it over with one of our knowledgeable professionals.

Learn more about the biological alternatives that have been authorised by the FDA, such as enclomiphene citrate or gonadorelin, if you are presently utilising HCG as part of your Hormone Replacement Therapy.

What exactly is clomiphene citrate, though?


Multiple published studies found that using enclomiphene citrate resulted in a rise in blood total testosterone that was within the normal range, as well as an increase in LH and FSH levels that were higher than the usual range. After discontinuing medication, the effects on LH and total testosterone were still detectable at least a week later. However, enclomiphene is being used in combination with testosterone treatment to preserve sperm function in males. At the present time, it has not been shown if the use of enclomiphene may be considered an adequate substitute or alternative for testosterone therapy (TRT).

Enclomiphene is a non-steroidal oestrogen receptor antagonist that has been in the process of being developed for the treatment of secondary thyroid problems in overweight men who are looking to restore normal testicular function. Clomid, also known as clomiphene citrate, has been FDA-approved since 1967 for the treatment of infertility in women. However, clomiphene citrate has also been widely was using off-label in men to increase fertility and retain sperm quality and testis feature in men who are taking external oestrogen. Enclomiphene is the purified isomer of Clomid. Enclomiphene works by stimulating and enlarging the testicles, which leads to the production of luteinizing hormone (LH) and follicle stimulating (FSH). These hormones are responsible for the natural and endogenous production of testosterone and sperm in the body. Initial investigations revealed that enclomiphene preserves the androgenic advantage of clomiphene citrate without the negative effects that are related to zuclomiphene, which is active in the conventional clomiphene citrate formulation.

When the testicles are stimulated to produce testosterone and estradiol at a higher level than normal, it is possible for men to have negative side effects. The possibility for excessive stimulation of the testicles will cause some men to feel a dull aching feeling in their testicles. It is possible that the patient has to have their dose decreased if they are experiencing an excessive stimulation of their testes. It is possible to verify if gonadorelin or enclomiphene are successful in activating the pituitary gland and testes by including lab tests for luteinizing hormone (LH) and follicle stimulating (FSH) on their blood test panels.

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Disclaimer:

This material is provided just for your general understanding and is not meant to serve as a substitute for the advice or treatment of a qualified medical professional for any particular medical problem. The material is only offered in a condensed manner, and its primary purpose is to provide a comprehensive comprehension and breadth of knowledge. The material should not be regarded complete, and it should not be used as a substitute for a visit to your doctor or another healthcare practitioner, a phone conversation with them, a consultation with them, or their advice. Nobody but a trained doctor can tell you whether or not you are eligible for therapy and whether or not you should get it.

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