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Selective Androgen Receptor Modulators (SARMs)– What Athletes Required to Know
What are SARMs?
Selective Androgen Receptor Modulators (SARMs) are a class of healing compounds that have comparable anabolic residential or commercial properties to anabolic steroids, but with decreased androgenic (producing male qualities) residential or commercial properties. As an example, the androgen receptor is activated by binding androgens, such as testosterone. Unlike anabolic steroids, which bind to androgen receptors in many tissues all over the body, individual SARMs selectively bind androgen receptors in specific tissues, however not in others.
In medical settings, this could be very helpful for stimulating specific tissue development like muscle and bone, while preventing undesirable adverse effects in other tissues like the liver or skin. SARMs are being examined as a medical treatment for muscle-wasting triggered by several diseases, such as osteoporosis, cancer, cardiac arrest, persistent obstructive lung disease, end-stage liver disease, end-stage kidney disease, and HIV.
To date, all SARMs are for investigational functions only.
Are SARMs restricted on the World Anti-Doping Firm (WADA) Prohibited List?
All SARMs are forbidden at all times (both in and out-of-competition) for all professional athletes, from those contending at the highest level of sport to those contending at the recreational level. SARMs are listed in the classification of “Other Anabolic Agents” under section S1.2 of the WADA Prohibited List.
Examples of SARMs include: ostarine (Enobosarm, MK 2866), andarine, LGD-4033 (ligandrol), and RAD140.  SARMs have the potential to be misused for performance enhancement in sport due to their anabolic residential or commercial properties, along with their capability to stimulate androgen receptors in muscle and bone, causing bone and muscle growth.
What if my medical professional recommends a SARM for me?
There are no Food and Drug Administration (FDA)- approved SARMs presently offered for prescription. All SARMs are investigational drugs, so it is not legal for your physician to recommend a SARM. Professional athletes who want to participate in scientific trials including prohibited substances must contact USADA for a Healing Usage Exemption (TUE).
What are the health threats related to SARMS?
The FDA has actually alerted customers about prospective deadly side effects from SARMs, including an increased threat of cardiovascular disease and stroke.
The long-lasting effects of using SARMs are unidentified.
Can SARMs be found in dietary supplements?
SARMs are not legal ingredients for any dietary supplements. However, there are many dietary supplements on the market that are polluted with, or market to consist of, SARMs.
Currently, there are more than 120 of these items noted on the Supplement 411 High Threat List. Dietary supplements including SARMs could position substantial health risks to professional athletes and cause a positive test. Professional athletes need to understand that SARM components could be listed on dietary supplement item labels under various names.
The following are examples of SARMs that are frequently and illegally marketed in dietary supplements or as research study chemicals:
- Ostarine (Enobosarm, MK2866, S22).
- Andarine (S4).
- LGD-4033 (Ligandrol).
- RAD140 (Testolone).
The following forbidden substances are also at some point marketed as SARMs:
- SR9009 (Stenabolic).
- Ibutamoren (MK-677, Nutrabol).
- GW501516 (GW1516, Cardarine, Endurobol).
What are the number of Unfavorable Analytical Findings (AAFs) for SARMs?
SARMs were added to the WADA Prohibited List in 2008 and the first AAF with a SARM drug candidate was reported in 2010. Ever since, there has been a constant increase in the number of AAFs involving SARMs reported globally. In the U.S., SARMs have been associated with more than 50 sanctions, and worldwide, SARMs have actually accounted for more than 230 favorable tests given that 2012.
 Zhang X, Sui Z. Figuring out the selective androgen receptor modulators paradigm. Specialist Opin Drug Discov. 2013; 8( 2 ):191 -218. http://www.ncbi.nlm.nih.gov/pubmed/23231475.
Chen J, Kim J, Dalton J. Discovery and restorative promise of selective androgen receptor modulators. Mol Interv. 2005; 5( 3 ):173 -188.
Geyer H, Schänzer W, Thevis M. Anabolic agents: current techniques for their detection and protection from unintended doping. Br J Sports Med 2014; 48:820 -826. Image credit to this short article, Figure 6, p. 5.
Knoop A, Krug O, Voncenti M, Schanzer W, Thevis M. In vetro metabolism research studies on the selective androgen receptor modulator (SARM) LG121071 and its application into human doping controls utilizing liquid chromatography-mass spectrometry. Eur J Mass Spectrom 2015; 21( 1 ):27 -36.
 U.S. Department of Defense Dietary Supplement Resource. SARMS: What’s the damage? Obtained July 17, 2020, from https://www.opss.org/article/sarms-whats-harm.
 U.S. Fda, Department of Health and Human Providers. Biogenix U.S.A., LLC warning letter, December 11, 2014. Recovered November 12, 2015, from http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/ucm434928.htm.
World Anti-Doping Firm (WADA) Lab Screening Stats. Accessed July 2020, from https://www.wada-ama.org/en/resources/laboratories/anti-doping-testing-figures-report.
Selective Androgen Receptor Modulators (SARMs) are a class of restorative substances that have similar anabolic properties to anabolic steroids, but with minimized androgenic (producing male characteristics) homes. Unlike anabolic steroids, which bind to androgen receptors in many tissues all over the body, private SARMs selectively bind androgen receptors in specific tissues, but not in others.
All SARMs are investigational drugs, so it is not legal for your doctor to prescribe a SARM. SARMs were added to the WADA Prohibited List in 2008 and the very first AAF with a SARM drug candidate was reported in 2010. In the U.S., SARMs have been associated with more than 50 sanctions, and internationally, SARMs have accounted for more than 230 favorable tests given that 2012.
SARMs Products (Shop)
- Sarms Capsules and Droppers
- Sarms stacks
- Sarms Test Base Supplement
- Sarms Post Cycle Therapy Supplement
- Sarms Cycle Support Supplement
- S4 (Andarine)
- MK-2866 (Ostarine)
- RAD-140 (Testolone)
Learn More About SARMs
Read More about SARMs
Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands.
They are intended to have the same kind of effects as androgenic drugs but be much more selective in their action, allowing them to be used for more uses than the relatively limited legitimate uses of anabolic steroids. SARMs signify a new era of tissue-selective androgens with an unknown potential to treat (and possibly cure) several diseases.
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